ALB and neoplasm: Non-biodegradable nanoparticles, such as bovine serum albumin conjugated with polymethyl methacrylate, show higher penetration and deeper accumulation in the tumor via repeated mediated endocytosis and exocytosis processes, but this higher rate of penetration will provide resistance to the sufficient intercellular release of drugs leading to comparatively lower cytotoxicity, as comparable to biodegradable nanoparticles such as bovine serum albumin conjugated with polycaprolactone.