It is composed of non-malignant cells of tumor-like cancer-associated fibroblasts (CAFs) (Raghu et al., 2016; Tang et al., 2016; Lee et al., 2018; Liu et al., 2019; Monteran and Erez, 2019; Wang et al., 2019; Yavuz et al., 2019), tumor-associated macrophages (TAMs) (Qian et al., 2009; Noy and Pollard, 2014; Larionova et al., 2019; Lin et al., 2019), tumor-associated neutrophils (TANs), mesenchymal stem cells and extracellular matrix (ECM) with fibrous structural proteins (e.g., collagen and elastin), fibrous adhesive proteins (e.g., laminin and fibronectin), and proteoglycans. Here, FN1 is linked to neoplasm.