IC50 values (μM) complexes 2a–2f in HCT116, NCI-H460, SiHa and SW480 cancer cell lines expressed as mean ± standard error (n = 3), in comparison to ligand 2 and the homodimetallic analogs Ru2, Os2, Rh2 and Ir2 (Steel et al., 2021). The gene discussed is MATN3; the disease is cancer.