However, compared with healthy controls, MMP-2/TIMP-1 and MMP-9/TIMP-1 ratios were significantly associated with macrophage accumulation (Figures 1G,J) and granulation tissue (Figures 1H,K) related to PSP recurrence, and with fibrosis (Figures 1I,L) related to surgery. This evidence concerns the gene MMP9 and supranuclear palsy, progressive, 1.