TIMP1 and supranuclear palsy, progressive, 1: However, compared with healthy controls, MMP-2/TIMP-1 and MMP-9/TIMP-1 ratios were significantly associated with macrophage accumulation (Figures 1G,J) and granulation tissue (Figures 1H,K) related to PSP recurrence, and with fibrosis (Figures 1I,L) related to surgery.