MTOR and neoplasm: Bleomycin shrinks hemangioma through multiple mechanisms, such as suppressing the metabolism of tumor cells by directly degrading DNA, which then accelerates tumor cell necrosis (17), destroying endothelial cells by the formation of microthrombi in hemangioma sinuses, leading to atrophy and fibrosis of the hemangioma (18) and obliterating the vascular lumen by activating the mTOR pathway and inducing non-specific inflammatory processes around the hemangioma (19).