It is also important to realize that the influence of founder variants is significant: for example, the homozygous p.F531C variant in DSG2 was associated with a fully penetrant heart failure phenotype in a Chinese cohort (34), while the TMEM43 p.S358L variant in addition to conveying a high risk of sudden cardiac death is associated with LV dysfunction (31). Here, TMEM43 is linked to heart failure.