PTK2 and non-small cell lung carcinoma: For example, in NSCLC, FOCAD-FAK signaling was shown to be involved in cysteine deprivation-induced ferroptosis, and NRF2 was shown to inhibit the FOCAD-FAK signaling axis and induce ferroptosis via increasing the activity of Complex I in the mitochondrial electron transport chain (ETC) and TCA cycle.