NFE2L2 and lung adenocarcinoma: * “Lapatinib and siramesine induce synergistic cell death in lung adenocarcinoma”* “Lapatinib and siramesine treatment increased reactive iron, ROS, and induced ferroptosis through decreasing heme oxygenase-1 (HO-1) protein expression.”* “Decrease in HO-1 expression was due to proteasome degradation and confirms that Nrf2 is not implicated in the regulation of HO-1”