Recent studies have identified that GPX4 is not the only ferroptosis suppressor in human cancer cells, and ferroptosis suppressor protein 1 (FSP1, formerly known as AIFM2) independent of GSH suppresses lipid peroxidation and subsequent ferroptosis through converting ubiquinone (coenzyme Q10, CoQ10) to ubiquinol (CoQH2, reduced form of CoQ10) using an NADPH-consuming reduction reaction (Figure 1). This evidence concerns the gene AIFM2 and cancer.