SOX2 and lung cancer: For example, a recent study has elucidated that there is a positive relationship between the level of transcription factor SOX2 and SLC7A11 in lung cancer stem-like cells (CSLC), and upregulation of SOX2 in lung tumors can highly inhibit ferroptosis and increase resistance to imidazole ketone erastin (IKE), a strong inducer of ferroptosis (14).