showed that iron-dependent enzymes Egl nine homolog (EGLNs) under hypoxia conditions degrades HIF-1α (Figure 3), leading to increased lymphoid-specific helicase (LSH) expression, a chromatin remodeling factor that acts as an oncogene and ferroptosis inhibitor in lung cancer via increasing the expression of SCD1 (48, 49). Here, HIF1A is linked to lung cancer.