Selinexor did not reduce total protein levels of HLA-E in SUDHL4 lymphoma cells (Figures 2F, G) and therefore XPO1 mediated downregulation of surface HLA-E was not due to targeted inhibition of HLA-E protein production, but more likely was a result of a reduction in supply of other HLA-E binding substrates that lead to HLA-E upregulation. Here, HLA-E is linked to lymphoma.