Disruption of constant de novo protein synthesis has previously been shown to selectively downregulate HLA-E surface expression (34) and this therefore provides a potential mechanism for selective HLA-E downregulation on lymphoma cells by selinexor and leptomycin B. Interestingly, HLA-E has also been shown to be downregulated by bortezomib via ER stress in multiple myeloma (34) and by the CDK inhibitor dinaciclib in AML (47). Here, HLA-E is linked to acute myeloid leukemia.