IDH3A and central nervous system cancer: In glioma with non-mutated isocitrate dehydrogenase (IDH), branched-chain amino acids such as leucine and isoleucine, and their catabolizing enzyme branched-chain amino acid transaminase 1 (BCAT1), are more expressed – in turn, BCAT1 knock-down in glioma cells reduces the viability of glioma cells (39).