It has been documented that regulating autophagy-related signaling pathways, such as PI3K/Akt/mTOR, p53and JAK/STAT, can significantly affect epithelial-mesenchymal transition, which may be drivers of tumor aggravation, and thus may result in adverse outcomes in tumor growth and metastasis, and even drug resistance (36). This evidence concerns the gene SOAT1 and neoplasm.