CEACAM5 and neoplasm: Furthermore, adding preoperative serum tumor markers (CEA, CA19-9, and CA125) or the Immunoscore to a model that combined all clinical variables (gender, age, pT stage, pN stage, tumor location, tumor CSA, tumor long axis, tumor differentiation, lymphatic infiltration, vascular infiltration, and nerve infiltration) significantly improved both DFS (likelihood ratio: p = 0.0052 and p = 0.0276, respectively) and OS (likelihood ratio: p = 0.0004 and p = 0.0117, respectively) prediction (Supplementary Figures S3A, B).