TP53 and myelodysplastic syndrome: While TP53 mutation is associated with a complex karyotype (especially del(5q) and 17qLOH), and generally predicts a dismal outcome regardless of therapeutic interventions (60, 61), SF3B1 mutation (which is commonly found in MDS ring sideroblast; MDS-RS) is associated with favorable outcome and is now recognized as a discrete type of myeloid neoplasm (62).