uncovered the higher ITGB2 expression in CAFs promote tumor proliferation in OSCC by activating the PI3K/AKT/mTOR pathways and NADH oxidation in the mitochondrial oxidative phosphorylation system (62), and ITGB2 was found to be involved in the proliferation, migration, and invasion of CRC cells (63). This evidence concerns the gene ITGB2 and neoplasm.