AKT1 and colorectal carcinoma: uncovered the higher ITGB2 expression in CAFs promote tumor proliferation in OSCC by activating the PI3K/AKT/mTOR pathways and NADH oxidation in the mitochondrial oxidative phosphorylation system (62), and ITGB2 was found to be involved in the proliferation, migration, and invasion of CRC cells (63).