Notably, these frequently mutated genes in our cohort were significantly associated with functional categories involved negative regulation of gene expression, epigenetic (H3F3A and DNMT3A), and virus infections such as cytomegalovirus, EBV, HIV, and papillomavirus infections (e.g., GNAS, GNAQ, HLA-A, and HLA-B). This evidence concerns the gene HLA-A and viral infectious disease.