In line with the evidence that canonical Wnt signaling plays an important role in the development and progression of B-cell lymphomas (35), in our study population, we inferred the novel TCF7L2_WT1 gene fusion may associate with B-cell lymphomas progression through triggering the dysregulation of Wnt signaling. The gene discussed is TCF7L2; the disease is B-cell non-Hodgkin lymphoma.