Through comparing preferentially mutated genes between our cohort and 413 DLBCL tissues samples from COSMIC database, we found some genes were especially mutated with high frequencies in our cohort such as GNAQ, GNAS, H3F3A, DNMT3A, HLA-A, and HLA-B, in addition to nine overlapped genes (e.g., TP53, KMT2D, MYD88, ATM, and BCL2). Here, DNMT3A is linked to diffuse large B-cell lymphoma.