GNAS and viral infectious disease: KEGG pathway analysis showed that the mutated genes were significantly associated with virus infections involved pathways such as human T-cell leukemia virus 1 infection (e.g., HLA-A and HLA-B), cytomegalovirus infection (e.g., HLA-A, HLA-B, GNAQ, GNAS, and GNA13), Epstein-Barr virus (EBV) infection (e.g., HLA-A and HLA-B), human immunodeficiency virus 1 (HIV) infection (e.g., HLA-A, HLA-B, and GNAQ), and papillomavirus infection (e.g., HLA-A, HLA-B, and GNAS) (Figure 2).