Of note, there were nine preference mutated genes (e.g., TP53, KMT2D, CREBBP, BCL2, ATM, and PIM1) that were overlapped between the top 30 frequently mutated genes of our results, and the top 20 frequently mutated genes detected in lymphoid tissues of 413 DLBCL patients from COSMIC database. Here, BCL2 is linked to diffuse large B-cell lymphoma.