Second, referring to our previous results, hZIP1 plays a vital role in the progression of renal cancer, knockdown of hZIP1 increases the proliferation and invasion of ACHN cells, and overexpression of hZIP1 diminishes the formation of tumors in nude mice by targeting GAS5/miR-223 (17, 18). The gene discussed is GAS5; the disease is renal carcinoma.