While an association between PD-L1 expression level or TMB and the responses to ICI has not been consistently observed across all driver alterations, the overall lack of response to ICI treatment appeared to be more common among NSCLC with driver alterations that are typically associated with non-smokers, raising the question whether the absence of tobacco exposure may predict the lack of benefit from ICI treatment. This evidence concerns the gene CD274 and non-small cell lung carcinoma.