The introduction of ICIs, such as anti-programmed cell death protein ligand 1 (anti-PD-L1) and anti-programmed cell death protein 1 (anti-PD-1) antibodies, as well as the anti-cytotoxic T-lymphocyte-associated protein 4 (anti-CTLA-4) antibody, have revolutionized the treatment of NSCLC, and is typically offered with or without chemotherapy in the front-line setting for incurable NSCLC that does not have any actionable mutations (2). Here, CTLA4 is linked to non-small cell lung carcinoma.