A study based on a Chinese population with the CHEK2 mutation in 74 patients with BC with FH and 50 control subjects identified that the missense variant of CHEK2 in these cases was 1111C>T (His371Tyr) instead of CHEK2.1100delC, which implies that the CHEK2.1100delC variant was relatively rare in the Chinese population and that CHEK2 c.1111C>T mutation might be related to the genetic susceptibility of BC (105). Here, CHEK2 is linked to breast cancer.