MET and hereditary leiomyomatosis and renal cell cancer: A number of hereditary RCC syndromes have been identified (12), such as Von Hippel-Lindau (VHL) disease, Birt-Hogg-Dubé (BHD) syndrome, Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC), and Hereditary Papillary RCC (HPRC), which is caused by germline mutations in VHL, BHD, FH and MET, respectively.