In summary, by comparing the biological behavior, prognosis, and molecular level of FNMTC and SNMTC, we draw conclusion that the biological behavior and prognosis of FNMTC were no more aggressive and worse than SNMTC, and BRAF V600E and TERT also provided a genetic explanation for this conclusion. This evidence concerns the gene BRAF and familial papillary or follicular thyroid carcinoma.