Yet studies done with p16 and p53 tumor expression in carcinoma breast among Indian patients are scanty. Hence, the association of p53 and p16 overexpression in carcinoma breast with various prognostic parameters like age, histopathological type, tumor grade, mitosis along with ER, PR and HER2neu expression was assessed in the present study. The gene discussed is CDKN2A; the disease is neoplasm.