ASCVD: Atherosclerotic cardiovascular disease; MI: Myocardial infarction; CV: Cardiovascular; HF: Heart Failure; ESKD: End-stage kidney disease; CKD: Chronic kidney disease; NYHA: New York Heart Association; HFrEF: Heart failure with reduced ejection fraction; HFpEF: Heart failure with preserved ejection fraction; KCCQ: Kansas City Cardiomyopathy Questionnaire; eGFR: Estimated glomerular filtration rate; 3-point MACE: Non-fatal MI, non-fatal stroke or CV death; 4-point MACE: Non-fatal MI, non-fatal stroke, CV death, and unstable angina hospitalization; SGLT-2: Sodium-glucose co-transporter-2. The gene discussed is SLC5A2; the disease is chronic kidney disease.