FD: Fabry disease; α-GAL-A: alpha-galactosidase-A; Gb3: globotriaosylceramide; TIA: transient ischemic attack; NIHSS: National Institutes of Health Stroke Scale; mRS: modified Rankin scale; GVUS: genetic variants of unknown significance; CT: computed tomography; MRI: magnetic resonance imaging. The gene discussed is GLA; the disease is Stroke.