GLA and Fabry disease: Gb3: globotriaosylceramide; GVUS: genetic variants of unknown significance; ERT: enzyme replacement therapy; TIA: transient ischemic attack; mRS: modified Rankin scale; MCA: middle cerebral artery; PCA: posterior cerebral artery; α-GAL-A: alpha-galactosidase-A; MRI: magnetic resonance imaging; WMHs: white matter hyperintensities; CKD: chronic kidney disease; GI: gastrointestinal; FD: Fabry disease