Notably, nobiletin exerted memory‐improving effects in a number of animal models of AD such as olfactory‐bulbectomized mice, Aβ‐infused rats, MK‐801‐treated mice, senescence‐accelerated mice, amyloid precursor protein Tg mice, and a rat model of cerebral ischemia Nakajima and Ohizumi (2019). This evidence concerns the gene APP and brain ischemia.