Our results indicated that the activity of SOD in varicocele (4.54 ± 0.26) and varicocele reserving solvent (4.21 ± 0.045) groups significantly increased compared with control (3.38 ± 0.10) and lycopene groups (4 and 10 mg/kg, 3.7 ± 0.14 and 3.6 ± 0.13, respectively) (p < .05, Figure 5). The gene discussed is SOD1; the disease is varicocele.