We observed a significant decrease in the activity of catalase (CAT) in the varicocele (0.19 ± 0.04) and varicocele reserving solvent (0.21 ± 0.03) groups compared with the control group (0.32 ± 0.026) (p < .05), but these changes were not significant between lycopene groups (4 and 10 mg/kg, 0.25 ± 0.024 and 0.27 ± 0.005, respectively) and to control group (p > .05, Figure 5). This evidence concerns the gene CAT and varicocele.