Compared with wild type, IL15 knockout mice had significantly improved survival in CLP‐induced sepsis, along with reduced NK and CD8+ cells and mitigated sepsis‐induced hypothermia and organ injuries, and the severity of sepsis was restored by exogenous infusion of IL15 owing to activating NK cells (Orinska et al., 2007). The gene discussed is CD8A; the disease is Sepsis.