In CHF patients, LVEF (r = 0.728, P < 0.001) and FS (r = 0.679, P < 0.001) were positively correlated with NO/ET-1, while E/A was negatively correlated with NO/ET-1 (R = −0.822, P < 0.001), as shown in Figure 1. This evidence concerns the gene EDN1 and congestive heart failure.