Interestingly, compared with the control supernatants, administration of the supernatant from the PA group on Raw264.7 cells had decreased the mRNA levels of key inflammatory cytokines and chemokines including Tnf alpha, Il-6, Il1b, C–C chemokine ligand 5 (Ccl5), Ccl7, C-X-C motif chemokine ligand-2 (Cxcl2), and Cxcl10 (Figure 3(c)), which were similar to the lower immune reactions observed in HFD-sepsis mice. Here, IL6 is linked to Sepsis.