To further investigate whether the improvement effect of PCE on hyperlipidemia was associated with the regulation of the PI3K/AKT pathway, FOXO3 and ERα expression, western blotting, and immunofluorescence were performed to analyze the effect of PCE on p-AKT, AKT, ERα protein expression, and FOXO3 transfer. This evidence concerns the gene ESR1 and hyperlipidemia.