In this study, we combined the KDM1A-binding components and KDM1A expression-related genes for downstream analyses and evaluated the potential roles of KDM1A on “cell cycle pathway,” “RNA transport pathway,” “DNA binding,” and “RNA splicing.” The intersection of KDM1A-binding components and KDM1A-related genes included HDAC2 and SMARCA4, which indicated the efficacy of KDM1A on cancer mainly through cooperating with other epigenetic regulatory factors to finely regulate downstream genes. Here, HDAC2 is linked to cancer.