In support, evidence from multiple studies indicated that the expression of NOTCH-related genes, NOTCH1, NOTCH2, delta-like 4 (DLL4), and Hes1 is significantly higher in gastric cancer tissue, where NOTCH1, NOTCH2, NOTCH3, and DLL4 were significantly associated with worse tumor characteristics [23]. This evidence concerns the gene HES1 and neoplasm.