The analysis of 375 STAD tumor samples and 32 healthy control samples (Figure 1(c)) showed significant overexpression of 10 genes (NOTCH1, NOTCH2, NOTCH3, NOTCH4, DLL1, DLL4, JAG1, JAG2, HES1, and HEY1) in STAD tumor samples compared with healthy control samples, whereas the expression of DDL1 was not significantly different between control and cancer samples. The gene discussed is NOTCH4; the disease is cancer.