TGFB1 and metastatic malignant neoplasm in the lymph nodes: Gaur P discovered that the expression levels of Interleukins 4 (IL-4) and IL-10 and Transforming Growth Factor (TGF-β) in the central region of OSCC are closely related to the activity of Th2 cells, which results in the inhibition of immune function, local infiltration, and lymph node metastasis [92].