Because there is no pancreatic tissue gene expression data for human acute pancreatitis in the GEO database, we analyzed the differential expression of genes in the mouse acute pancreatitis dataset GSE119844 and found that the differential expression trend of genes TNF, NOS3, and TGFB1 is consistent with that in this study (Supplementary Table S1), that is, in the inflammation samples, TNF and TGFB are upregulated, and NOS3 is downregulated. Here, NOS3 is linked to acute pancreatitis.