In turn, the increase in Ang II levels activates the AT1 receptor, the overactivation of this signaling induces deleterious actions as progression of cardiovascular diseases, end-organs injury, cell growth, vascular contraction, fibrosis, inflammatory responses and salt and water retention, which undoubtedly, on its own, impairs the health of the infected patient [92]. The gene discussed is AGT; the disease is cardiovascular disorder.