Though, small molecule drugs such as cannabidiol and miltirone may induce HCC cell death through GSDME-mediated pyroptosis (Zhang et al., 2020b; Shangguan et al., 2021), non-cleavable or pore-defective GSDME was also proved to be not tumor suppressing (Zhang et al., 2020a). This evidence concerns the gene GSDME and hepatocellular carcinoma.