TNFAIP8 and neoplasm: Tumor necrosis factor-α–induced protein 8 (TNFAIP8) is a member of the TIPE/TNFAIP8 family, which was first found in human head and neck squamous cell carcinoma (Patel et al., 1997), and play important roles in immunity, oncogenesis, and tumor progression (Lou and Liu, 2011).