Few data further shed light on TNFAIP8 in immune response processes, including an increasing trend of TNFAIP8 mRNA levels in tumor-infiltrating CD4+ CD8+ T cells (Duan et al., 2014) and the tendency of CD4+ T cells immune function modulation both in mice and humans (Chu et al., 2003; Xin et al., 2016). Here, CD4 is linked to neoplasm.