AZU1, BPI, TCF7L2, and WFIKKN1 were upregulated in sciatica patients, while ANGPTL4, CRP, EREG, FAM19A4, FGF1, LOC100129216, PLXNB1, RLN1, and RXFP2 were downregulated. Here, RXFP2 is linked to Sciatica.