Thirteen DEIRGs (AZU1, BPI, TCF7L2, WFIKKN1, ANGPTL4, CRP, EREG, FAM19A4, FGF1, LOC100129216, PLXNB1, RLN1, and RXFP2) between sciatica patients and healthy controls were obtained using the inclusion criteria log∣FC∣ > 0.2 and p < 0.001. The gene discussed is PLXNB1; the disease is Sciatica.