We also found that the pr-lncRNA GPRC5D-AS1 showed negative correlations with the expression levels of major histocompatibility complex I (MHC I) and MHC II (Figure 5F and Supplementary Figure S2A) that assist in tumor cell recognition and antigen presentation (Lauss et al., 2017), indicating that a high expression of GPRC5D-AS1 may reduce tumor immunogenicity. This evidence concerns the gene GPRC5D and neoplasm.