TBL1XR1 and cancer: The lncRNA GPRC5D-AS1 with CNVs driving the dysregulation of downstream cancer genes such as PRKCI, SEM1, TBL1XR1, IMPACT, and RPL22L1 further disturbed the activities of NOTCH signaling pathway that is usually inactivated in LUSC (Katoh and Katoh, 2020) (Figure 6B,C).