NLRP3 and amyotrophic lateral sclerosis: The result of GSEA showed that the KEGG pathway gene set of the metabolism of glycolipid metabolism, tyrosine metabolism, starch and sucrose metabolism, arginine and proline metabolism, valine leucine and isoleucine degradation, cell adhesion molecules cams, pentose and glucuronate interaction, amyotrophic lateral sclerosis (Figure 6A), and the Reactome pathway gene set of the NLRP3 inflammasome, signaling to Ras, and signaling to ERKs, and other three pathway was significantly enriched in the control group (Figure 6B).