The upregulated matrix metallopeptidase, including MMP-1, −3, −7, −10, −11, −13, −14, −16, −26, and −28, are favoring the invasion and metastasis (Scheau et al., 2019), while MMP1, MMP13, and MMP28 were significantly downregulated in the AC093797.1 overexpressed HCC cell HCCLM3, suggesting that this may be one of the reasons AC093797.1 inhibited the migration and invasion of HCC cells. This evidence concerns the gene MMP28 and hepatocellular carcinoma.