CASP4 and telomere syndrome: We found that 34 PRGs were differentially expressed (p < 0.05), among which 14 genes (CASP3, CASP5, CASP6, DHX9, GSDMA, GZMA, GZMB, IL1B, NLRC4, NLRP3, NLRP7, NOD2, PYCARD, TNF) were upregulated and 20 genes (APIP, CASP4, CASP8, CASP9, ELANE, FOXO3, GPX4, GSDMB, GSDMC, GSDME, IL18, IL6, NLRP1, NLRP2, NLRP6, NOD1, PJVK, PLCG1, PRKACA, SCAF11) were downregulated in STS group (Figure 2A, Supplementary Figure S1A).