To explore whether the SLC39A family genes affect the tumor immune infiltrating and microenvironment in pan-cancer, the TIMER 2.0 was used to evaluate the relationship between the SLC39A family gene expression levels and the infiltration of six common immune cells, including B cells, CD4+ T cells, CD8+ T cells, Treg T cells, macrophages, and neutrophils. This evidence concerns the gene CD4 and neoplasm.