Concomitantly, the disruption of major genes by de novo BCA breakpoints leading to major AD developmental disorders, as retrieved by SVInterpreter, indicated the pathogenicity of ANKRD11 (OMIM *611192; proband DGRC0016) and WDR26 (OMIM *617424; proband DGRC0025) (David et al., 2020). The gene discussed is ANKRD11; the disease is Alzheimer disease.