We then explored the genetic differences between pure HPV-infection and HPV-int tumors and verified that PIK3CA, TTN, MUC4, KMT2C, and SYNE1 were common somatic mutations both in pure HPV-infection and HPV-int women, suggesting that these genes play an important role in HPV-associated cervical cancer. The gene discussed is SYNE1; the disease is cervical carcinoma.