Maternal bi-allelic variants of KHDC3L are known to cause recurrent hydatidiform mole, an aberrant human pregnancy featuring early embryonic arrest and excessive trophoblastic proliferation (Nguyen et al., 2018), while heterozygous deletions (p.150_160del and p.150_172del) were found in patients experiencing RPL without forming an hydatidiform mole (Zhang et al., 2019). Here, KHDC3L is linked to hydatidiform mole.