The Cytoscape with cytoHubba tool kits, GEPIA, and c-BioPortal analysis suggested that upregulated hub genes of MRPL22, MRPL28, MRPL21, MRPL12, MRPS12, and MRPL17 are correlated with poor overall survival and may play a key role by cooperating with ALDOA in lung adenocarcinoma. This evidence concerns the gene MRPL21 and lung adenocarcinoma.