Methylation levels of microRNA-124–2 (miR-124–2), was significantly associated with HIV positive women with low, moderate and severe grade neoplasia compared to HIV negative women (124); however, no association was found between the methylation content of the tumour suppressor genes CADM1, MAL RARB, DAPK1 and PAX1 in HIV (124, 125). The gene discussed is RARB; the disease is neoplasm.