The mechanism is dependent on increased expression of miR-92a-3p, which directly inhibits Fbxw7 and moap1 and activates Wnt/β-Catenin pathway to inhibit mitochondrial apoptosis and promote stem cell differentiation, the EMT, metastasis and 5-FU/L-OHP resistance in CRC cells (50). The gene discussed is MOAP1; the disease is colorectal carcinoma.