EGFR is a membrane-bound receptor tyrosine kinase protein that activates downstream intracellular signaling pathways, including MAPK (RAS/RAF/MEK/ERK), PI3K/AKT, and JAK/STAT3 signaling, and plays a role in tumor cell growth, proliferation and differentiation (206, 207). This evidence concerns the gene NTRK1 and neoplasm.