JAK2 and colorectal carcinoma: When HT-29 or HCT116 cells are co-cultured with TAMs (THP-1 cells stimulated by conditioned medium from a CRC cell line), TAM derived IL-6 activates the JAK2/STAT3 pathway, which results in increased FoxQ1 expression, leads to the production of CCL2 and promotes the recruitment of macrophages, thus enhancing the migration and invasion of CRC cells (59).