IFNB1 and viral infectious disease: Together with past studies using other viruses, including IAV and Coxsackievirus B3, or sterile virus-like stimulation with poly I:C, this study indicates that PAR2 expression and activation contributes to viral infection-associated pathology by enhancing proinflammatory TLR3-NFκB responses and reducing antiviral TLR3-IFNβ responses as first suggested first by Nhu et al.