BNIP3 and neoplasm: We analyzed 16 known HIF-1 related genes and found that 15 were significantly overexpressed in tumor samples in the meta-PDAC cohort, including ALDOA, ALDOC, ENO1, GAPDH, HIF1A, HK1, HK2, LDHA, PDK1, PFKFB3, PFKL, PGK1, PKM, SLC2A1, and SLCS2A3, whereas only one (BNIP3) was significantly downregulated (Figure S1A).