We analyzed 16 known HIF-1 related genes and found that 15 were significantly overexpressed in tumor samples in the meta-PDAC cohort, including ALDOA, ALDOC, ENO1, GAPDH, HIF1A, HK1, HK2, LDHA, PDK1, PFKFB3, PFKL, PGK1, PKM, SLC2A1, and SLCS2A3, whereas only one (BNIP3) was significantly downregulated (Figure S1A). This evidence concerns the gene PKM and neoplasm.