This patient was the focus of our 2020 MODS paper (75), where we discovered the 16 yo patient to have Hemophagocytic lymphohistiocytosis (HLH) likely driven by a dominant-negative splicing variant in RNASEH2B that is activated by the EBV suppression of nonsense-mediated decay. Here, RNASEH2B is linked to hemophagocytic syndrome.