A large proportion of proteins upregulated in the HT group was related to immune response, such as annexin A6 (ANXA6), calreticulin (CALR), cyclase associated actin cytoskeleton regulatory protein 1 (CAP1), major histocompatibility complex, class I, A (HLA-A), heat shock protein family D (Hsp60) member 1 (HSPD1), methyltransferase like 7A (METTL7A), prothymosin alpha (PTMA), ubiquitin conjugating enzyme E2 O (UBE2O), suggesting that the autoimmune system of patients with HT may have been disordered. This evidence concerns the gene ANXA6 and hematocrit.