CD8A and neoplasm: Conversely, higher β-HPV RNA and DNA were found in cSCC of immunosuppressed patients relative to their immunocompetent counterparts, and CD8+ T cells isolated from human tumor tissues responded to peptides from the E7 protein of commensal β-HPV, but not to the oncogenic HPV-16, suggesting that immunocompetent patients had active immune responses against β-HPV operating in the TME (168).