Also, progression of tumor cells through cell cycling after the genotoxic stimulus led to the accumulation of cytoplasmic micronuclei that were recognized by cGAS, leading to IFN production and T cell priming, indicating that beyond DCs, tumor cell sensing of damaged DNA via STING pathway also contributes to IFN-I production and cancer immune responses (70) (Figure 3). The gene discussed is CGAS; the disease is cancer.