IFN-I-induced transcripts correlated with T cell infiltration in human melanoma and mice models have shown that IFN-I can be produced by intratumoral DCs upon tumor implantation, being indispensable for the accumulation of intratumor cross-presenting dendritic cells and priming of CD8+ T cells (60) (Figures 2, 3). The gene discussed is CD8A; the disease is melanoma.