Furthermore, these epigenetic modulators can exert direct effects on immune cells: HDACi and DHA treatment were shown to selectively deplete myeloid derived suppressor cells (MDSCs), leading to improved response to ICB in preclinical models (232); also, DHA treatment directly enhanced CD8+ T cell effector function and promoted better tumor control by modulating differential expression of NFAT isoforms, which favored the T cell differentiation into effector cells and inhibited their terminal differentiation into exhausted cells (233). Here, CD8A is linked to neoplasm.