The more restricted expression of IFNLR1 and IL10RB as opposed to IFNAR1 and IFNAR2 (which are ubiquitously expressed by nucleated cells) and the known attenuated inflammatory potential of IFN-III in comparison to IFN-I has led to the hypothesis that IFN-III administration would exert anti-tumor activities with less toxicity compared to IFN-I (30, 85). Here, IFNAR1 is linked to neoplasm.